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用抗体捕获法，建丘了检测荷C3d－IgM类免疫复合物（CMIC）的ELISA技术。经对临床疾病研究发现，由HBV引起的肝病组中，血清存在有高水平的CMIC，阳性检出率为29．0％～46．1％。不同病程其CMIC前后水平亦有差异．在乙型肝炎急性期，CMIC阳性水平最高，并呈上升趋势，慢性活动性肝炎及慢性重症肝炎似有下降，而在慢性迁延性肝炎和有HBV引起的肝硬化患者中，CMIC含量又有所回升。在10例CMIC持续阳性者中，有9例为慢性肝炎，似提示该类免疫复合物的持续存在，则有可能预示疾病的慢性化。
Antibody capture method was used to establish an ELISA technique for detecting C3d-IgM immunocomplexes (CMICs). The study on clinical diseases found that there was a high level of CMIC in the serum of HBV-induced liver disease, with a positive rate of 29.0% -46.1%. Different course of CMIC before and after the level is also different. In the acute stage of hepatitis B, the positive level of CMIC is the highest, and there is an upward trend. Chronic active hepatitis and chronic severe hepatitis may appear to decline. However, in patients with chronic persistent hepatitis and HBV-induced liver cirrhosis, the CMIC level is somewhat higher Pick up. Among 10 CMIC persistent positives, 9 were chronic hepatitis, suggesting that the persistence of such immunocomplex might predict chronic disease.