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目的:建立奥美拉唑碳酸氢钠氢氧化镁片溶出度测定方法。方法:以水为溶出介质,采用高效液相色谱法测定奥美拉唑碳酸氢钠氢氧化镁片的溶出度。结果:奥美拉唑线性方程为A=5.45×10~5C-7.58×10~4(r=0.999 9)线性范围:4.0~40.0μg·ml~(-1)。平均回收率为99.86%;RSD为0.42%。结论:本法可用于奥美拉唑碳酸氢钠氢氧化镁片溶出度测定。
Objective: To establish a method for the determination of dissolution of omeprazole sodium bicarbonate magnesium hydroxide tablets. Methods: Dissolution rate of omeprazole sodium bicarbonate magnesium hydroxide tablets was determined by high performance liquid chromatography with water as dissolution medium. Results: The linear equation of omeprazole was A = 5.45 × 10-5C-7.58 × 10-4 (r = 0.999 9) linear range: 4.0-40.0μg · ml -1. The average recovery was 99.86%; RSD was 0.42%. Conclusion: This method can be used to determine the dissolution of omeprazole sodium bicarbonate magnesium hydroxide tablets.