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目的探讨细胞间粘附分子 1 (ICAM 1 )、白细胞介素 8(IL 8)在支气管哮喘 (哮喘 )、慢性阻塞性肺病 (COPD)发病机制中的作用和吸入皮质激素对哮喘、COPD患者的影响。方法 6 0例COPD急性发作期患者随机分为一般治疗组 30例 (COPDⅠ组 )和加用吸入激素组 30例 (COPDⅡ组 ) ,哮喘急性发作期 1 5例及健康对照组 30例。各病例组分别于入院时及治疗 2周后取静脉血 4ml,同时测峰值呼气流速 (PEF)。IL 8采用放免法、ICAM 1采用ELLISA法测定。结果 3组治疗前后ICAM 1、IL 8水平均显著高于对照组 (P <0 0 1或P <0 0 5 ) ,其PEF显著低于对照组 (P <0 0 1 ) ,治疗后ICAM 1、IL 8水平显著低于急性发作期 (P <0 0 1或P <0 0 5 ) ,其PEF有明显改善 (P <0 0 1 ) ;哮喘治疗前后ICAM 1、IL 8水平显著低于COPDⅠ、Ⅱ组治疗前后 (P <0 0 1或P <0 0 5 ) ,其PEF显著高于COPDⅠ、Ⅱ组 (P <0 0 1 ) ;COPDⅠ组治疗前后与COPDⅡ组治疗前后比较ICAM 1、IL 8水平差异无显著性 (P >0 0 5 ) ,但COPDⅡ组治疗后PEF改善显著优于COPDⅠ组 (P <0 0 1 )。结论ICAM 1、IL 8在哮喘、慢性阻塞性肺病气道炎症的形成中起着重要作用 ,哮喘急性发作期短期吸入皮质激素可抑制ICAM 1、IL 8表达 ,而在COPD急性发作期患者短期吸入皮质激素并?
Objective To investigate the role of intercellular adhesion molecule 1 (ICAM 1), interleukin 8 (IL 8) in the pathogenesis of bronchial asthma (asthma) and chronic obstructive pulmonary disease (COPD) and the effect of inhaled corticosteroids on asthma and COPD influences. Methods Sixty patients with acute exacerbation of COPD were randomly divided into general treatment group (30 cases) and inhaled steroid group (30 cases), acute exacerbation of asthma (15 cases) and healthy control group (30 cases). In each case group, 4 ml of venous blood was taken at admission and 2 weeks after treatment, respectively, and mean peak expiratory flow (PEF) was measured. IL 8 was radioimmunoassay, and ICAM 1 was determined by ELLISA. Results The levels of ICAM 1 and IL 8 in three groups before and after treatment were significantly higher than those in the control group (P <0.01 or P <0.05), and their PEF were significantly lower than those in the control group (P <0.01) , IL-8 levels were significantly lower than acute exacerbation (P <0.01 or P <0.05), PEF was significantly improved (P <0.01); before and after asthma treatment ICAM 1, IL 8 levels were significantly lower than COPD Ⅰ , Before and after treatment in group Ⅱ (P <0.01 or P <0 05), the PEF was significantly higher than that in COPD Ⅰ and Ⅱ groups (P <0.01); Before and after treatment in COPD groupⅠ and before and after treatment with COPD groupⅡ, ICAM 1, IL 8 levels (P> 0.05). However, the PEF improvement in COPD group was significantly better than that in COPD group (P <0.01). Conclusions ICAM 1 and IL 8 play an important role in the formation of airway inflammation in asthma and chronic obstructive pulmonary disease. Short-term inhaled corticosteroids can inhibit the expression of ICAM 1 and IL 8 in the acute phase of asthma. Corticosteroids and?