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目的 观察小剂量米非司酮治疗子宫异常出血的疗效.方法 采用每日5mg的小剂量米非司酮治疗顽固性子宫异常出血26例,其中功血症18例,粘膜下子宫肌瘤2例,子宫内膜息肉4例,子宫肥大症2例.所有病人的子宫≤50天孕大.结果 26例病人全部闭经,贫血情况得到明显改善.停药后仍有10例病人继续闭经在3个月以上.13例病人停药后出现少量月经,无须治疗.3例病人停药后阴道流血接近治疗前,重新服药后闭经.8例病人伴有继发性痛经消失.3例病人出现潮热,1例继发轻微腹泻.结论 每日5mg小剂量米非司酮治疗子宫异常出血疗效可靠,副作用轻.
Objective To observe the efficacy of low-dose mifepristone in treating abnormal uterine bleeding.Methods Twenty-six patients with intractable abnormal uterine bleeding were treated with low dose of 5 mg mifepristone, including 18 cases of dyslipidemia and 2 cases of submucosal uterine fibroids , 4 cases of endometrial polyps, 2 cases of uterine hypertrophy.All patients with uterine ≤50 days pregnant large.Results 26 cases of patients with amenorrhea, anemia was significantly improved.After stopping the treatment of 10 patients still amenorrhea in 3 Month or more .13 patients after stopping a small amount of menstruation, no treatment .3 patients after stopping vaginal bleeding before treatment, re-medication after amenorrhea .8 patients with secondary dysmenorrhea disappeared .3 patients had hot flashes , 1 case of mild secondary diarrhea.Conclusion The low daily dose of 5mg mifepristone for the treatment of abnormal uterine bleeding is reliable and the side effects are mild.