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本文采用放射免疫分析法检测64例梗阻性黄疸病人(服消炎痛组n=32,未服消炎痛组n=32)手术前后外周血浆血栓素A_2和前列环素（PGI_2）的稳定代谢产物TXB_2和6-K-PGF_（1α）浓度,结果表明,未服消炎痛组术前血浆TXB_2、6-K-PGF_（1α）浓度及T/P显著升高,尤以TXB_2升高明显(p<0.01)。术后血浆TXB_2、6-K-PGF_（1α）下降,但TXB_2仍高于无黄疸组水平,T/P无明显变化(p>0.05)。服药组上述指标术前降至无黄疸组水平(p<0.01),术后与术前相比无明显差异(p>0.05)。说明TXA_2、PGI_2参与梗阻性黄疸的病理生理变化。
In this paper, 64 patients with obstructive jaundice (n = 32 without indomethacin and n = 32 without indomethacin) were detected by radioimmunoassay (RIA). The stable metabolites of thromboxane A 2 and prostacyclin (PGI 2) 6-K-PGF_ (1α) and 6-K-PGF_ (1α) in plasma of patients without indomethacin, the TXB_2, 6-K-PGF_ (1α) 0.01). The postoperative TXB_2, 6-K-PGF_ (1α) decreased, but the level of TXB_2 was still higher than that of non-jaundice group. There was no significant change in T / P (p> 0.05). The above indexes in the medication group were reduced to no jaundice group before operation (p <0.01), and there was no significant difference between before and after operation (p> 0.05). TXA_2, PGI_2 involved in the pathophysiology of obstructive jaundice.