目的　对患者进行肝功能和 B超检查 ,观察有机硒的治疗效果。方法　切断高砷水源 ,改饮低砷水 ,服用有机硒治疗。结果　肝功能阳性和肝肿大检出率分别为 15 .0 8%和 2 0 .2 4% ,且与临床症状、体征改变程度无关 ,男性高于女性 ,其中二者并发率仅 4.76 %。硒治疗组肝功能阳性转阴率 80 .0 0 % ,对照组 46 .15 % ,肝肿大硒治疗组痊愈 33.33% ,好转 2 9.17% ,总有效率 6 2 .5 0 % ,对照组痊愈 7.6 9% ,好转 2 3.0 8% ,总有效率 30 .77% ,加重 46 .15 % ,两组均有显著差异。结论　硒对地方性砷中毒肝脏损害有显著疗效 Objective To perform liver function tests and B-ultrasound in patients and observe the therapeutic effect of organic selenium. Methods Cut off high-arsenic water, change drinking low arsenic water, take organic selenium treatment. Results The positive rates of liver function and hepatomegaly were 15.0% and 20.24%, respectively, which were not related to the clinical symptoms and signs, and were higher in males than in females, of which the rates of both were only 4.76%. Selenium treatment group liver function positive rate of 80.0%, control group 46.15%, hepatomegaly selenium treatment group cured 33.33%, improved 2 9.17%, the total effective rate 62.50%, the control group recovered 7.69%, improvement of 3.08%, the total effective rate of 30.77%, an increase of 46.15%, there were significant differences between the two groups. Conclusion Selenium has a significant effect on liver damage caused by endemic arsenism