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1脑缺血后Caspases介导的细胞死亡大量研究显示脑缺血可导致Caspases的激活。在脑缺血再灌注模型中神经元凋亡发生前有Caspase3的激活与上调,特别是在海马、尾状核、豆状核;全脑缺血再灌注可引起Caspase3介导的ICAD裂解,产生的CAD导致DNA的凋亡样裂解;使用Caspase3活性抑制剂可
1 Caspases-mediated cell death after cerebral ischemia A large number of studies have shown that cerebral ischemia can lead to the activation of Caspases. Activation and up-regulation of Caspase3 in neuronal apoptosis occurs in cerebral ischemia-reperfusion model, especially in the hippocampus, caudate nucleus and lentiform nucleus. Whole-brain ischemia-reperfusion can induce Caspase3-mediated ICAD cleavage Of CAD leads to apoptotic DNA fragmentation; inhibitors of Caspase3 activity can be used