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目的:研究鼠曲草乙酸乙酯部位化学成分。方法:采用硅胶柱色谱、Sephadex LH-20等分离纯化手段相结合对鼠曲草进行分离纯化。通过理化性质和波谱数据(1H-NMR,13C-NMR)进行结构鉴定。结果:从鼠曲草中分离鉴定了13个化合物,分别鉴定为咖啡酸乙酯(1),原儿茶酸乙酯(2),对羟基肉桂酸(3),4-羟基苯乙酮(4),原儿茶酸(5),3-(4’-formylphenoxy)-4-methoxybenzaldehyde(6),desmethylyangonine-4’-glucopyranoside(7),4’-hydroxydehydrokawain(8),绿原酸(9),1,4,5-三咖啡酰奎宁酸(10),1,5-二咖啡酰奎宁酸(11),1,5-二咖啡酰奎宁酸甲酯(12),1,3-二咖啡酰奎宁酸(13)。结论:化合物1,2,4~7,10为首次从鼠曲草属植物中分离得到,化合物3,8为首次从菊科植物中分离得到。
Objective: To study the chemical constituents of the ethyl acetate of Squilin. Methods: Silica gel column chromatography and Sephadex LH-20 separation and purification methods were used to separate and purify. The structure was identified by physicochemical properties and spectroscopic data (1H-NMR, 13C-NMR). Results: Thirteen compounds were isolated and identified from the genus Curcuma respectively and identified as caffeic acid ethyl ester (1), protocatechuic acid ethyl ester (2), p-hydroxycinnamic acid (3), 4-hydroxyacetophenone 4, 4-hydroxydehydrokawain (8), chlorogenic acid (9), protocatechuic acid (5) ), 1,5-tacalciferylquinic acid (10), 1,5-dicaffeoylquinic acid (11), methyl 1,5-dicaffecaquinate (12) 3-Dicaffeoylquinic acid (13). CONCLUSION: Compounds 1, 2, 4 ~ 7 and 10 were isolated from the genus Glycine for the first time. Compounds 3 and 8 were isolated from Compositae for the first time.