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在动物界,下丘脑在调节食物摄入中起重要作用。先天性或获得性功能紊乱均可导致肥胖。作者以前已经报告了在某些严重肥胖妇女中有下丘脑功能的紊乱。最近,作者又认为可根据在胰岛素所诱导的低血糖时PRL的反应性把肥胖分成二种不同类型。一种对PRL没有反应,此种肥胖往往从童年开始,并有肥胖的家族史;另一种PRL反应正常,肥胖往往在生命后期发生。但如静注TRH,直接作用于垂体,在二组病人中PRL反应性均正常。因此,作者提出是否无PRL反应的这种类型的肥胖提示有一基本的,可能有遗传参与的下丘脑功能紊乱,作者报告12例在经空回肠手术治疗后一年,体重明显减轻的肥胖病人的情况。 所有病人甲状腺功能正常,住院期间给予80g/天的碳水化合物,对这些病人用胰岛素诱导低血
In the animal kingdom, the hypothalamus plays an important role in regulating food intake. Congenital or acquired dysfunction can lead to obesity. The authors have previously reported disorders of hypothalamic function in some severely obese women. Recently, the authors concluded that obesity can be divided into two different types based on the reactivity of PRL at insulin-induced hypoglycemia. One that does not respond to PRL, which often starts in childhood and has a obese family history; another PRL responds normally and obesity tends to occur late in life. However, such as intravenous TRH, a direct effect on the pituitary, PRL reactivity in both groups of patients were normal. Therefore, the authors propose that this type of obesity with or without PRL response suggests that there is a basic hypothalamic disorder that may be genetically involved, and the authors report 12 patients with obese patients who had a significant weight loss one year after empty ileal surgery Happening. Thyroid function was normal in all patients with 80 g / day of carbohydrates given during hospitalization, and hypoglycemia was induced in these patients with insulin