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作者对4家规模较小的制鞋厂中40名接触含正己烷50%以上的粘胶剂及洗液的工人(男10名,女30名;接触工龄1～28年)进行了研究,旨在评价工人尿中排泄的2,5-己二酮与接触正己烷的制鞋工人神经病的神经肌电图改变之间是否存在着相关关系。工人每日工作7小时,只接触一种粘胶剂或洗液,无防护措施,以前未接触过工业神经毒物。工作一周后,收集工人的尿样,用气相色谱法分析正己烷及其异构体的代谢产物,同时使用肌电仪对接触工人进行电生理学诊断检查,用Allen等的方法对肌电检查所见进行评价。结果发现40人中有39人尿中正己烷的代谢产物主要为2,5-己二酮,其浓度平均为6.8 mg/L,最高达
The authors conducted a study of 40 workers (10 males, 30 females and 1 to 28 years of working experience) exposed to 50% or more of n-hexane adhesives and lotions in 4 smaller shoe factories, Aim To assess whether there is a correlation between 2,5-hexanedione excreted in the urine of workers and changes in neuromuscular patterns of neuropathy in n-hexane shoe-contacting workers. Workers working 7 hours a day, only exposed to a glue or lotion, no protective measures, had not been exposed to industrial nerve poison. After a week’s work, the urine samples of workers were collected and the metabolites of n-hexane and its isomers were analyzed by gas chromatography. Electromyography was also used to detect contact with workers. The method of Allen et al. See evaluation. As a result, 39 metabolites of n-hexane in 40 persons were found to be mainly 2,5-hexanedione, with an average concentration of 6.8 mg / L, up to