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应用免疫组织化学双标记技术对急性轻型和慢性活动型乙型病毒性肝炎各２０例活检肝组织中的Ｆａｓ抗原和增殖细胞核抗原（ＰＣＮＡ）进行了检测。Ｆａｓ抗原表达于肝细胞胞浆内，急、慢性肝炎肝组织中Ｆａｓ抗原检出率分别为６０．０％及８０．０％，ＰＣＮＡ于肝细胞核内表达，其检出率均为８５．０％。两种抗原阳性细胞可各自弥散分布于肝小叶内，但在点灶性和碎屑状坏死灶周围较为密集多见。结果表明，病毒性肝炎时肝组织中Ｆａｓ抗原和ＰＣＮＡ的分布密切相关，肝细胞损伤愈明显，其再生修复能力也愈强。
The immunohistochemical double labeling technique was used to detect Fas antigen and proliferating cell nuclear antigen (PCNA) in 20 biopsied liver tissues of acute and chronic active hepatitis B virus. Fas antigen was expressed in the cytoplasm of hepatocytes. The positive rates of Fas antigen in liver tissues of acute and chronic hepatitis were 60.0% and 80.0%, respectively. The positive rates of PCNA expression in hepatocytes were 85.0% %. Two kinds of antigen-positive cells can be dispersed in the hepatic lobule, but in the focal and detritus necrosis more dense around more common. The results showed that the distribution of Fas antigen and PCNA in liver tissue was closely related to viral hepatitis, and the more obvious the liver cell injury was, the stronger the ability of regenerative repair was.