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目的:探讨垂体腺瘤侵袭及复发与抑癌基因p16蛋白表达的关系。方法 :通过免疫组化方法检测57例垂体腺瘤中 p16蛋白的表达水平 ,并对患者进行5年随访对比研究。结果:垂体腺瘤组织中 p16蛋白阳性率为31.6% ,侵袭性组 p16蛋白阳性率显著低于非侵袭性组 (P<0.01)。11例复发组 p16蛋白阳性率为0,显著低于41例未复发组 p16蛋白阳性率36.6% (P<0.01)。不同激素分泌功能垂体腺瘤 p16蛋白表达率无显著差异。结论:p16蛋白表达水平可作为临床评价垂体腺瘤侵袭性和预测患者复发的指标。
Objective: To investigate the relationship between the invasion and recurrence of pituitary adenoma and the expression of p16 protein. Methods : The expression of p16 protein in 57 pituitary adenomas was detected by immunohistochemistry and the patients were followed up for 5 years. Results: The positive rate of p16 protein in pituitary adenomas was 31.6%, and the positive rate of p16 protein in invasive group was significantly lower than that in non-invasive group (P<0.01). The positive rate of p16 protein in the 11 relapsed group was 0, which was significantly lower than that of the 41 non-recurrent group (36.6%) (P<0.01). There was no significant difference in the expression of p16 protein in pituitary adenomas with different hormone secretion. Conclusion: The expression level of p16 protein can be used as a clinical indicator to evaluate the invasiveness of pituitary adenomas and predict patient recurrence.