己酮可可碱为磷酸二酯酶抑制药 ,能增加细胞内cAMP ,并有改善血流动力学、免疫抑制和抗纤维化的作用 ,它越来越广泛地应用于临床 ,发挥着老药新用的作用。本文综述该药的药动学、作用机制、临床应用及不良反应等方面的研究进展 Pentoxifylline is a phosphodiesterase inhibitor that increases intracellular cAMP and improves hemodynamics, immunosuppression and antifibrosis. It is used more and more widely in the clinic and plays an important role in the development of new drugs Use of the role. This article reviews the pharmacokinetics, mechanism of action, clinical application and adverse reactions of the drug