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目的探讨静脉应用小剂量红霉素后不同校正胎龄早产儿早期喂养出现的疗效差别。方法选择2011—2013年间校正胎龄>32周及≤32周时开始经口喂养早产儿各30例,分别随机分成大胎龄红霉素组(n=15)、大胎龄对照组(n=15)和小胎龄红霉素组(n=15)、小胎龄对照组(n=15),两个红霉素治疗组在常规治疗的基础上采用小剂量红霉素3~5 mg/kg静滴,1次/d,疗程7 d。两个对照组均采用常规治疗。测量并比较各组早产儿相关营养和生长发育指标。结果大胎龄红霉素组与大胎龄对照组相比较,其恢复出生体质量时间、全胃肠道营养时间及体质量平均增长速度差异有统计学意义(P<0.05),但小胎龄红霉素组与小胎龄对照组比较差异无统计学意义(P>0.05)。结论红霉素能有效改善校正胎龄>32周开始经口喂养的早产儿营养状况,促进其早期体格发育,但对≤32周开始经口喂养的早产儿无效。
Objective To investigate the differences in curative effects of early feeding of different gestational age preterm infants after intravenous administration of low dose of erythromycin. Methods 30 preterm infants were randomly divided into three groups: normotensive group (n = 15), gestational age (n = 15), n (N = 15), small gestational age control group (n = 15), two erythromycin treatment groups on the basis of conventional treatment with low-dose erythromycin 3 to 5 mg / kg intravenous infusion, 1 time / d, treatment of 7 d. Both control groups were treated routinely. Measure and compare the nutrition and growth and development of preterm infants in each group. Results Compared with the gestational age group, the reproductive body mass time, the total gastrointestinal nutrition time and the average growth rate of body weight in erythromycin group were statistically significant (P <0.05) There was no significant difference between the erythromycin group and the gestational age control group (P> 0.05). Conclusion Erythromycin can effectively improve the nutritional status of oral feeding of preterm infants corrected for gestational age> 32 weeks and promote their early physical development. However, they are ineffective for preterm infants orally started ≤32 weeks.