论文部分内容阅读
本文对药效学模型的发展和应用作一评述,特别注意药物代谢动力学和药效学的综合研究。这种综合方法可用以描述剂量-效应之间的全面关系,并有助于设计合理的剂量方案。“药物代谢动力学”简称药代动力学(Ph-armacokinetics)和“药效学”(Pharmacodyna-mics)这两个术语的含义可用图la和b表示。前者描述一次或多次剂量后药物浓度随时间的
This article reviews the development and application of pharmacodynamic models with particular attention to the comprehensive study of pharmacokinetics and pharmacodynamics. This comprehensive approach can be used to describe the overall relationship between dose-response and help design a reasonable dosage regimen. The meanings of the terms “Pharmacokinetics”, Ph-armacokinetics and Pharmacodyna-mics, are shown in Figures la and b. The former describes the concentration of a drug over time after one or more doses