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目的介绍结直肠癌Lewis-Selectin转移途径和西咪替丁抗癌辅助治疗的研究进展。方法收集近年来国内、外有关Lewis-Selectin转移途径和西咪替丁抗转移辅助治疗研究的文献并作综述。结果在Lewis抗原,唾液酸化LewisX(sLeX)在结直肠癌中表达阳性率最高,肿瘤细胞借助细胞表面sLeX与激活的血管内皮细胞的E-selectin和P-selectin相互作用,从而促使肿瘤侵袭和转移;西咪替丁可提高宿主对肿瘤细胞的免疫反应,影响肿瘤新生血管的生成,具有抑制肿瘤生长和转移的重要作用,且对sLeX阳性的结直肠癌患者的疗效要好于阴性者。结论 Lewis-Selectin转移途径是结直肠癌重要转移途径之一,西咪替丁对sLeX高水平表达的结直肠癌患者有一定的抗转移治疗作用。
Objective To introduce the research progress of Lewis-Selectin metastasis and cimetidine anticancer adjuvant therapy for colorectal cancer. Methods The literature about Lewis-Selectin metastasis and cimetidine anti-metastasis adjuvant therapy in recent years was collected and reviewed. Results In Lewis antigen, the sialyl Lewis X (sLeX) expressed the highest positive rate in colorectal cancer. Tumor cells interacted with E-selectin and P-selectin in activated vascular endothelial cells through cell surface sLeX to promote tumor invasion and metastasis ; Cimetidine can improve host immune response to tumor cells, affecting tumor angiogenesis, with the important role of inhibiting tumor growth and metastasis, and sLEX-positive patients with colorectal cancer is better than the negative effect. Conclusions Lewis-Selectin metastasis is one of the important metastatic pathways of colorectal cancer. Cimetidine has a certain anti-metastatic effect on patients with colorectal cancer with high expression of sLeX.