免疫毒素是抗体与毒素构建的交联物。由于抗体特别是单克隆抗体对肿瘤抗原的特异识别作用,及多种毒素对肿瘤细胞杀伤的高效性,以免疫毒素作为“生物导弹”用于肿瘤的导向治疗已成为可能。免疫毒素最大的优点是毒性强,是化学药物的上万倍,以较少的抗体就可制备有效杀伤肿瘤细胞的免疫毒素。除原已发现的毒素外,在微生物、植物中又不断发现了新的高效毒素。目前免疫毒素研 Immunotoxins are cross-linked constructions of antibodies and toxins. Due to the specific recognition of tumor antigens by antibodies, especially monoclonal antibodies, and the high efficiency of multiple toxins in killing tumor cells, it has become possible to use immunotoxins as a “bio- missile” for the targeted treatment of tumors. The greatest advantage of immunotoxins is their high toxicity, which is tens of thousands of times that of chemical drugs. Immunotoxins that are effective in killing tumor cells can be prepared with fewer antibodies. In addition to the previously discovered toxins, new high-potency toxins have been found in microorganisms and plants. Current immunotoxin research