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用ELISA法测定了癫痫和其它神经精神病患者血小板中钙调素的含量。大发作及混合发作癫痫、视觉性癫痫、其它神经精神病患者(对照组)血小板中钙调素含量分别为7.59±2.83、3.33±1.11和2.75±1.14ug/mg蛋白(X±S)。大发作及混合发作癫痫与视觉性癫痫和对照组相比其钙调素含量均显著增高(P<0.01),而视觉性癫痫与对照组相比则无显著差异(P>0.05)。结果提示血小板中钙调素含量的测定可作为大发作及混合发作癫痫的辅助诊断。
The levels of calmodulin in platelets were measured by ELISA in patients with epilepsy and other neuropsychiatric disorders. Major episodes and mixed seizures, visual epilepsy, and other neuropsychiatric patients (control group) platelet calmodulin content were 7.59 ± 2.83,3.33 ± 1.11 and 2.75 ± 1.14ug / Mg protein (X ± S). Compared with the control group, the content of calmodulin in both epilepsy and mixed epilepsy was significantly increased (P <0.01), while there was no significant difference in visual epilepsy compared with the control group (P> 0.05 ). The results suggest that the determination of platelet content of calmodulin can be used as a secondary diagnosis of mixed seizures and epilepsy.