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抗癌疗法可引起肺部纤维性变,发病初期无明显症状,但进行性加重将导致致命的结果.麻醉和术后即刻增加吸入氧的浓度也会加重病情和引起隐性肺部纤维性变.所以,系统地观察加大氧浓度和对肺组织有毒性的广谱抗癌药发病机制,病理生理变化和药物的相互作用极为重要.临床上间质性肺炎进一步发展成肺纤维性变与抗癌药物引起肺毒性反应非常一致:如呼吸困难、干咳、肺基底部啰音及发烧等.病情逐渐发展在X线照片上
Anti-cancer therapy can cause lung fibrosis, early symptoms no obvious symptoms, but the progressive increase will lead to fatal results.Anesthesia and immediately after surgery to increase the concentration of inhaled oxygen can also aggravate the disease and cause recessive pulmonary fibrosis Therefore, it is very important to systematically observe the pathogenesis, pathophysiological changes and drug interactions of broad-spectrum anti-cancer drugs that increase the oxygen concentration and lung tissue toxicity.Clinical interstitial pneumonias further develop into pulmonary fibrosis and Anticancer drugs cause very consistent lung toxicity: such as dyspnea, dry cough, rales and fever at the base of the lungs, etc. The condition develops gradually on radiographs