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作者双盲交叉试验比较血管紧张素转换酶抑制剂苯酯丙脯酸与安慰剂治疗雷诺氏现象的效果。 17例病人随机接受苯酯丙脯酸和安慰剂治疗各3周,间隔2周,均在试验期的每天上午8小时给予,由逐日记载和药片计数实行监控。据冷刺激试验的客观指标和病人每日的主诉来判断两种治疗的效果。结果21天后,两组病人冷刺激试验无明显差异,但改善指收缩压降低超过20％者,苯酯丙脯酸2例,对照组1例。每日记录表明,苯酯丙脯酸
The authors double-blind crossover trial comparing angiotensin-converting enzyme inhibitor phenylpropion and placebo in treating Raynaud’s phenomenon. Seventeen patients were randomized to receive both phenylphenidate and placebo for 3 weeks at 2-week intervals, all at 8 hours a day during the trial period, monitored daily and recorded on tablets. According to cold stimulation test objective indicators and the patient’s daily complaints to determine the effect of the two treatments. Results After 21 days, there was no significant difference between the two groups in cold stimulation test, but improvement was found in systolic blood pressure reduction of more than 20%, phentermine 2 cases and control group 1 case. Daily records show phenylpropionate