本世纪初,Raab发现外源性光敏药物在特定波长的光照射下可引起生物体内的光反应。1924年,Policard发现内源性卟啉在人和动物肿瘤中的积聚。1961年,Lipson等阐述了血卟啉衍生物HPD的光动力特性及其在肿瘤治疗中的作用。1978年Dougherty首次成功地用先动疗法(Photodynamic therapy,PDT)治疗人乳腺癌皮肤转移,标志着现代临床PDT的开始。之后,临床PDT的研究得到广泛开展,涉及领域包括癌症、癌前期病变、非癌性异型增生、炎 At the beginning of this century, Raab found that exogenous photosensitive drugs can cause photoreactions in vivo under light irradiation at a specific wavelength. In 1924, Policard discovered the accumulation of endogenous porphyrins in human and animal tumors. In 1961, Lipson et al. Described the photodynamic properties of the hematoporphyrin derivative HPD and its role in tumor therapy. Dougherty’s first successful photodynamic therapy (PDT) in the treatment of human breast cancer skin metastasis in 1978 marked the beginning of modern clinical PDT. Since then, clinical PDT research has been widely carried out, covering areas such as cancer, precancerous lesions, non-cancerous dysplasia, inflammation