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目的探讨超敏C反应蛋白(hs-CRP)在急性脑梗死的诊断、病情监测和预后判定中的应用价值。方法采用胶乳增强免疫比浊法对110例急性脑梗死患者和38例健康体检者的血清hs-CRP含量进行测定比较。结果①脑梗死患者临床病情分型与血清hs-CRP的关系:轻型脑梗死组3.83±1.31mg/L,中型脑梗死组5.95±1.68mg/L,重型脑梗死组8.38±1.85mg/L,正常对照组1.28±0.79mg/L。脑梗死各组间血清hs-CRP含量两两比较差异均有显著性(P<0.01),脑梗死患者hs-CRP含量与其临床神经功能缺损程度评分呈正相关(r=0.683,P<0.01);②急性脑梗死患者治疗前后血清hs-CRP含量比较:治疗前为5.81±1.78mg/L,治疗两周后为1.52±1.28mg/L。急性脑梗死患者治疗前hs-CRP含量明显高于正常对照组(1.28±0.79mg/L)(P<0.01),治疗两周后与正常对照组无显著差异(P>0.05)。结论hs-CRP能反映脑梗死病情的严重程度,对于急性脑梗死的诊断、病情监测和预后判定具有一定价值。
Objective To investigate the value of hs-CRP in the diagnosis, prognosis and prognosis of acute cerebral infarction. Methods The serum hs-CRP levels in 110 patients with acute cerebral infarction and 38 healthy controls were measured by latex enhanced immunoturbidimetry. Results ① The relationship between the clinical classification and serum hs-CRP in patients with cerebral infarction: 3.83 ± 1.31mg / L in mild cerebral infarction group, 5.95 ± 1.68mg / L in middle cerebral infarction group and 8.38 ± 1.85mg / L in severe cerebral infarction group, Normal control group 1.28 ± 0.79mg / L. There was a significant difference in serum hs-CRP levels between the two groups (P <0.01). There was a positive correlation between hs-CRP levels and clinical neurological deficit scores in patients with cerebral infarction (r = 0.683, P <0.01). ② The levels of serum hs-CRP in patients with acute cerebral infarction before and after treatment were 5.81 ± 1.78mg / L and 1.52 ± 1.28mg / L after two weeks of treatment. The content of hs-CRP in patients with acute cerebral infarction before treatment was significantly higher than that in the normal control group (1.28 ± 0.79mg / L) (P <0.01). There was no significant difference between the two groups (P> 0.05). Conclusion hs-CRP can reflect the severity of cerebral infarction, and has certain value for the diagnosis, condition monitoring and prognosis of acute cerebral infarction.