本文采用1％巴豆油作为皮下组织的刺激剂,注入大鼠胸腰背部皮下,使局部形成皮下囊肿,复制出大鼠下囊肿模型,应用该模型测定了大鼠口服氟哌酸50mg/kg)后,皮下囊肿渗出液中药物的浓度。渗出液中氟哌酸的Tmax约为1.0h、Cmax为0.54μg/ml。用5％胃粘液素大肠杆菌1515悬液1m1(细菌数为8.5×10~6/ml),感染皮下囊肿后, In this paper, 1% croton oil as a subcutaneous tissue stimulant injected into the thoracolumbar and subcutaneous rats, the local formation of subcutaneous cysts, copy the rat under the cyst model, the model was used to determine the rat oral norfloxacin 50mg / kg) After the subcutaneous cyst exudate drug concentration. Norfloxacin in the exudate had a Tmax of about 1.0 h and a Cmax of 0.54 μg / ml. After inoculation of subcutaneous cyst with 1 ml of 5% gastric mucin E.coli 1515 suspension (bacteria number 8.5 × 10 ~ 6 / ml)