氟尿嘧啶(fluorouracil)作为多种实体瘤、包括乳腺癌和结肠直肠癌等化疗方案的主要组份已有几十年的历史了。但氟尿嘧啶的临床药理学十分复杂,其药代动力学在不同患者间、甚至在同一患者间也不一致,体内消除又呈非线性性质,口服生物利用度亦无规则。 Fluorouracil has been a staple of several solid tumors, including chemotherapy regimens such as breast and colorectal cancer, for decades. However, the clinical pharmacology of fluorouracil is very complex. The pharmacokinetics of fluorouracil are not the same among patients and even within the same patient. The in vivo elimination is non-linear and the oral bioavailability is also irregular.