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新近在呼吸道发现多种神经肽,其中 VIP 及 PHM 是强力的支气管扩张剂,也可能是呼吸道内非肾上腺素能抑制性神经的递质。哮喘时,如其在炎症细胞释放酶的作用下加快分解,可致支气管反应加剧。SP、神经激肽 A 及 CGRP 等感觉神经肽是通过轴反射从受刺激的无髓鞘神经末梢释放的,可参与哮喘发病。作者综述新近对呼吸道神经肽的一些研究,特别强调了神经肽在哮喘发病中的可能作用。
Recently found in the respiratory tract a variety of neuropeptides, including VIP and PHM is a powerful bronchodilator, respiratory tract may also be non-adrenergic inhibitory neurotransmitters. Asthma, as in the role of inflammatory cells to release enzymes to speed up the decomposition, can cause increased bronchial reactions. Sensory neuropeptides, such as SP, neurokinin A and CGRP, are released from stimulated myelinated nerve endings by axon reflection and may be involved in the pathogenesis of asthma. The authors review recent studies of neuropeptides in the respiratory tract, with particular emphasis on the possible role of neuropeptides in the pathogenesis of asthma.