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目的:观察乳酸菌阴道胶囊治疗妊娠合并外阴阴道念珠菌病的治疗效果及复发情况。方法:将310例患者随机分成两组,其中观察组160例,用2%-4%碳酸氢钠溶液冲洗后放置克霉唑及乳酸菌阴道胶囊联合治疗。对照组150例,用2%-4%碳酸氢钠溶液冲洗后放置制霉菌素治疗。结果:观察组痊愈103例,无效10例,复发18例,治愈率64.38%,总有效率93.75%,复发率11.25%;对照组痊愈80例,无效20例,复发38,治愈率53.33%,总有效率86.67%,复发率29.23%。观察组总有效率显著高于对照组,差异有统计学意义(p<0.05)。两组不良反应发生情况经统计学分析,差异无统计学意义(p>0.05)。结论:克霉唑及乳酸菌阴道胶囊联合治疗妊娠合并外阴阴道念珠菌病安全、可靠。
Objective: To observe the therapeutic effect and recurrence of lactic acid bacteria vaginal capsule in the treatment of vulvovaginal candidiasis in pregnancy. Methods: 310 patients were randomly divided into two groups, of which 160 cases in the observation group were treated with 2% -4% sodium bicarbonate solution and placed clotrimazole and lactic acid bacteria vaginal capsules combined treatment. The control group of 150 cases, with 2% -4% sodium bicarbonate solution placed nystatin treatment. Results: In the observation group, 103 cases were cured, 10 cases were ineffective, 18 cases were relapsed, the cure rate was 64.38%, the total effective rate was 93.75% and the recurrence rate was 11.25%. In the control group, 80 cases were cured, 20 cases were ineffective, The total effective rate was 86.67%, the recurrence rate was 29.23%. The total effective rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (p <0.05). Two groups of adverse reactions by statistical analysis, the difference was not statistically significant (p> 0.05). Conclusion: Combination of clotrimazole and lactic acid bacteria vaginal capsule in the treatment of vulvovaginal candidiasis in pregnancy is safe and reliable.