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目的:对清洁手术抗菌药物的应用进行分析,以提高临床抗菌药物使用的合理性。方法:抽取某院2009年6月-2010年7月共128例清洁手术患者的病历,对抗菌药物的应用情况进行统计、分析。结果:89.8%的患者应用了抗菌药物,所用抗菌药物共7大类27个品种,头孢菌素的费用(占抗菌药物费用的76.9%)及应用率(54.8%)均居首位,应用率依次是喹诺酮类(占20.2%)、硝基咪唑类(占13.1%)、氨基糖苷类(占10.0%)、青霉素类(占4.8%)、大环内酯类及磺胺类(各占0.6%)。使用率前5位的抗菌药物是头孢唑啉(占19.5%)、奥硝唑(占15.6%)、头孢孟多酯(占10.9%)、头孢替唑(占10.9%)、氧氟沙星(占10.9%)。结论:某院清洁手术抗菌药物的应用在品种选择及治疗用药上基本合理,但仍存在预防使用率过高、部分患者用药起点过高、预防用药选用不当、预防用药时间选择不合理、联用药物较多,及疗程过长等等问题,应当引起重视并进一步加强规范化使用的管理。
Objective: To analyze the application of clean surgical antibiotics to improve the rationality of clinical antibacterials. Methods: A total of 128 patients undergoing clean operation in a hospital from June 2009 to July 2010 were enrolled in this study. Statistics and analysis were made on the use of antibacterials. Results: Antimicrobial drugs were used in 89.8% of the patients, 27 varieties of 7 kinds of antibiotics were used, the cost of cephalosporin (accounting for 76.9% of the cost of antimicrobial drugs) and the rate of application (54.8%) ranked first, Followed by quinolones (20.2%), nitroimidazoles (13.1%), aminoglycosides (10.0%), penicillins (4.8%), macrolides and sulfonamides (0.6% ). The top 5 antibacterials were cefazolin (19.5%), ornidazole (15.6%), cefetamet (10.9%), ceftezole (10.9%), ofloxacin (10.9%). Conclusion: The application of antibacterials for cleaning surgery in a hospital is basically reasonable for variety selection and treatment. However, there are still some problems such as the high rate of prevention and treatment, the starting point of some patients being too high, the improper use of preventive medication, the unreasonable choice of preventive medication time, Drugs are more, and treatment is too long and so on, should pay attention to and further strengthen the standardized use of management.