对-羟基苯甲醛(1),具有一定抗癌活性,它又是多种药物、杀虫剂、染料和香料的重要中间体。我们按文献[2][3]的方法,以对甲苯酚(2)为原料,经氯化钴催化氧化法制备对-羟基苯甲醛(1)。该法工艺虽简单,路线短,但在产品中发现有对-羟基苯甲酸存在,影响了产品的质量,降低了收率。这是由于对羟基苯甲醛进一步氧化的结果。我们探索了于氯化钴催化剂中,添加硫酸铜的方法,避免了对羟基苯甲酸的生成,产品质量有所提高,取得了较为理想的效 Para-hydroxybenzaldehyde (1), which has some anticancer activity, is also an important intermediate for many drugs, pesticides, dyes and fragrances. We prepared p-hydroxybenzaldehyde (1) by catalytic oxidation of cobalt chloride using p-cresol (2) as a starting material in the literature [2] [3]. The process is simple, short route, but in the product found in the presence of p-hydroxybenzoic acid, affecting the quality of the product, reducing the yield. This is due to the further oxidation of p-hydroxybenzaldehyde. We explored the cobalt chloride catalyst, the method of adding copper sulfate, to avoid the formation of p-hydroxybenzoic acid, product quality has improved, and achieved better results