以叔丁醇作溶剂,在叔丁醇钠存在下,用相同的反应条件,以碘甲烷及一系列的溴代烷将α,β-二甲基丙基丙二酸二乙酯进行烃基化合成了一系列的带多侧链仲烃基的二烃基丙二酸二乙酯,其中有些化合物是第一次合成。求得了卤代烷结构和烃基化产率间的定量关系,即烃基化产率与卤代烷分子中烃基的诱导效应指数成规则的“S”曲线关系。 Using tert-butanol as a solvent, diethyl α, β-dimethylpropylmalonate was alkylated with methyl iodide and a series of brominated alkanes in the presence of sodium tert-butoxide using the same reaction conditions A series of dialkylmalonic acid diethyl esters with multi-sided secondary hydrocarbyl groups were synthesized, some of which were synthesized for the first time. The quantitative relationship between the structure of alkyl halides and the yield of alkylation was obtained, that is, the relationship between the yield of alkylation and the index of induction of alkyl groups in alkyl halides was a regular “S” curve.