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单纯疱疹病毒性脑炎(Herpes simplex virus encephalitis,HSE)又名急性坏死性出血性脑炎,是世界范围内最常见的致死性散发性脑炎,它是由单纯疱疹病毒(Herpes simplex virus,HSV)引起的急性中枢神经系统感染性疾病。HSE的发病机制尚未完全清楚。目前认为,病毒基因ICP34.5产物使机体宿主抗病毒的内源性干扰素系统失效而发挥致病作用[1]。此外,HSV-1诱导的神经细胞凋亡[2]及其介导的氧化损伤[3]也在发病中
Herpes simplex virus encephalitis (HSE), also known as acute necrotizing hemorrhagic encephalitis, is the world’s most common fatal sporadic encephalitis, which is caused by the herpes simplex virus (HSV ) Caused by acute central nervous system infectious diseases. The pathogenesis of HSE is not yet fully understood. It is currently believed that the production of the viral gene ICP34.5 will render the host system antiviral endogenous interferon system ineffective and play a causative role [1]. In addition, HSV-1-induced neuronal apoptosis [2] and its mediation of oxidative damage [3] also occur