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检测了４６例脑胶质瘤患者外周血淋巴细胞计数、淋巴细胞亚群、淋巴细胞转化试验（ＬＴＴ），同时对３４例脑胶质瘤局部浸润的单个核细胞进行了现察，结果发现患者外周血淋巴细胞数量、ＣＤ３、ＣＤ４亚群、ＣＤ４／ＣＤ８比值、ＬＴＴ等指标明显低于正常人。胶质瘤局部浸润的ＣＤ４亚群淋巴细胞数目明显少于ＣＤ８亚群、ＣＤ４／ＣＤ８比值为０．７９±０．１１．显著低于正常。３４例胶质瘤中仅有３～４例检测出Ｋｉ－６７、ＨＬＡ－Ｄｒ、ＣＤ２５阳性Ｔ细胞、ＣＤ２０阳性Ｂ细胞和ＣＤ５６阳性ＮＫ细胞，提示参与胶质瘤局部抗肿瘤免疫的主要是Ｔ淋巴细胞，而且大多处于非活化状态，ＮＫ细胞活性降低。
Peripheral blood lymphocyte count, lymphocyte subsets and lymphocyte transformation test (LTT) were detected in 46 patients with glioma. Meanwhile, 34 cases of locally infiltrating mononuclear cells of glioma were observed. The results showed that patients The number of peripheral blood lymphocytes, CD3, CD4 subsets, CD4 / CD8 ratio, LTT and other indicators were significantly lower than normal. The number of CD4 subpopulation lymphocytes locally infiltrated by glioma was significantly less than that of CD8 subpopulation, and the ratio of CD4 / CD8 was 0.79 ± 0.11. Significantly lower than normal. Ki-67, HLA-Dr, CD25-positive T cells, CD20-positive B cells and CD56-positive NK cells were detected only in 3-4 of 34 gliomas, suggesting that T-lymphocytes involved in local anti-tumor immunity of glioma are T Lymphocytes, but mostly in a non-activated state, NK cell activity decreased.