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目的:观察FOL、FOX化疗方案治疗晚期贲门癌患者改善生存质量及毒副作用发生情况。方法:将98例晚期贲门癌患者随机分为FOL组、FOX组,每组各49例,FOL组采用FOL方案,FOX组采用FOX方案。2组均以2周为1个治疗周期,治疗8个治疗周期后观察临床疗效、不良反应及生存质量改善情况。结果:2组有效率观察组为36.66%,对照组为17.24%,2组相比较差异有统计学意义(P<0.05)。2组均有不同程度的骨髓毒性反应,其中Ⅰ～Ⅱ级相比差异无统计学意义(P>0.05),Ⅲ～Ⅳ发生率相比差异有统计学意义(P<0.05)。2组均出现不程度呕吐症状,但观察组反应较轻,2组相比差异有统计学意义(P<0.05)。2组均有不同程度的外周神经毒性反应,但以Ⅰ～Ⅱ级为主,2组相比差异无统计学意义(P<0.05)。治疗后2组KPS评分均明显增高(P<0.05),治疗后组间相比差异有统计学意义(P<0.05)。结论:FOL、FOX化疗方案均对晚期贲门癌有较好的临床疗效,但FOL方案疗效更好,副作用更小,改善生存质量更为显著。
Objective: To observe the FOL, FOX chemotherapy for the treatment of advanced cardia cancer patients to improve the quality of life and the occurrence of side effects. Methods: A total of 98 patients with advanced cardia cancer were randomly divided into FOL group and FOX group, 49 cases in each group, FOL group in FOL group and FOX group in FOX group. Two groups were treated with two weeks as a treatment cycle. After eight cycles of treatment, clinical efficacy, adverse reactions and quality of life were observed. Results: The effective observation group was 36.66% in the two groups and 17.24% in the control group. There was significant difference between the two groups (P <0.05). There were different degrees of myelotoxic reactions in the two groups. There was no significant difference in grade Ⅰ ~ Ⅱ (P> 0.05). There was significant difference in the incidence of Ⅲ ~ Ⅳ between two groups (P <0.05). No symptoms of vomiting were observed in both groups, but the reaction in the observation group was mild, with significant difference between the two groups (P <0.05). There were different degrees of peripheral neurotoxicity in both groups, but they were mainly in grade Ⅰ ~ Ⅱ, but there was no significant difference between the two groups (P <0.05). After treatment, the scores of KPS in both groups were significantly increased (P <0.05). There was significant difference between the two groups after treatment (P <0.05). Conclusion: Both FOL and FOX chemotherapy have good clinical efficacy in advanced cardia cancer, but FOL has better curative effect, less side effects and better quality of life.