目的研究质子泵抑制剂在反流性食管炎维持治疗的临床疗效。方法将2009年3月12月门诊及住院的121例反流性食管炎并胃镜证实病灶已愈合,且停药1周内症状又复发者,随机分为A、B、C3组,3组均选用兰索拉唑。A组为兰索拉唑15mg,1次/d,早餐前服;B组为兰索拉唑15mg,1次/d,晚餐前服;C组兰索拉唑15mg,2次/d,餐前服。3组疗程均为4周。疗程结束后进行临床症状疗效评定,并予复查胃镜,评价3组胃镜下总有效率,并观察3组不良反应。结果三种方案有效率分别为77.5%、95.0%、92.7%。结论晚餐前15mg1次/d的兰索拉唑为反流性食管炎较佳维持治疗方案。 Objective To study the clinical efficacy of proton pump inhibitor in the treatment of reflux esophagitis. Methods 121 cases of reflux esophagitis and gastroscopy confirmed that the lesion had healed in outpatients and inpatients in March 2009 and December 12, and the symptoms were relapsed within 1 week after discontinuation of treatment. The patients were randomly divided into A, B and C3 groups and 3 groups Lansoprazole used. Group A was given lansoprazole 15mg once a day for breakfast before serving; Group B was lansoprazole 15mg once daily, before dinner; Group C lansoprazole 15mg twice daily, Former service. The three groups were treated for 4 weeks. After the end of the course of clinical efficacy evaluation, and to review the endoscopy, total gastroscopy evaluated three groups, and observed three adverse reactions. Results The three programs were effective rates were 77.5%, 95.0%, 92.7%. Conclusions Lansoprazole 15 mg once daily before dinner is the best maintenance treatment for reflux esophagitis.