不同临床类型硬皮病的原因至今尚不清楚,但免疫机理可能起重要作用。因硬皮病偶然与胶原性疾病及自身免疫性疾病如原发性胆管性肝硬变及溶血性贫血共存,并在硬皮病患者中经常可检出抗核抗体。最近报告的移植物抗宿主反应(GVHR)的皮肤改变,对进一步认识自发性硬皮病及扁平苔癣可 The reasons for different clinical types of scleroderma are unclear, but the immune mechanism may play an important role. Occasionally, scleroderma coexists with collagen and autoimmune diseases such as primary biliary cirrhosis and hemolytic anemia, and antinuclear antibodies can often be detected in patients with scleroderma. Recently reported skin graft-versus-host reaction (GVHR) changes in the skin, the further understanding of spontaneous sclerosis and lichen planus may