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通过实验性晶体过敏性色素膜炎(PAU)动物模型,观察了血中抗晶体抗体(ALAb)、血和房水中免疫复合物(IC)和前列腺素E_1(PGE_1)的动态变化;探讨了虹膜PGE_1和眼球病理改变的关系以及局部点滴消炎痛对PAU的作用。结果表明:PAU的发病和病理过程与全身和局部PGE_1水平下降、晶体蛋白的释放量、机体的致敏程度和IC的局部沉积有关;PAU的病理变化为非肉芽肿性炎症或Arthus反应:PGE_1可能作为重要的免疫或炎症抑制因子参与其病理过程:1％消炎痛局部应用未显示出对PAU的良好治疗作用。
The dynamic changes of anti-crystal antibodies (ALAb) in blood, immune complexes (IC) and prostaglandin E_1 (PGE_1) in blood and aqueous humor were observed in the experimental crystal allergic uveitis (PAU) animal model; The relationship between PGE_1 and the pathological changes of the eye and the effect of local indomethacin on PAU. The results showed that the pathogenesis and pathogenesis of PAU were related to the decrease of systemic and local PGE_1 levels, the release of crystal protein, the degree of sensitization of the body and local deposition of IC; the pathological changes of PAU were non-granulomatous inflammation or Arthus reaction: PGE_1 It may be involved in its pathological process as an important immune or inflammatory inhibitor: 1% indomethacin topical application does not show a good therapeutic effect on PAU.