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目的提高对非霍奇金淋巴瘤(NHL)中枢神经系统侵犯(CNSL)的认识。方法报告4例NHL的病理类型、治疗经过及影像报告检查结果,并复习相关文献。结果4例病理类型均为中高度恶性,均出现脑实质侵犯,1例尚合并脑膜侵犯,2例出现于病情完全缓解后。结论对具有中枢神经系统侵犯高危因素的NHL,在有效控制全身淋巴瘤的基础上,有必要早期进行脑脊液、影像学等检查,以便早期发现无症状CNSL患者,同时给予预防性化疗或放疗。
Objective To raise awareness of non-Hodgkin’s lymphoma (NHL) CNS invasion. Methods Four cases of NHL pathological type, treatment and imaging report examination results, and review the relevant literature. Results The pathological types of the four cases were all moderately and malignant, all of them had brain parenchymal invasion. One case had merger of meninges and two cases of complete remission. Conclusions On the basis of effective control of systemic lymphomas, it is necessary to carry out cerebrospinal fluid and imaging studies for the early diagnosis of asymptomatic CNSL in patients with NHL who are at risk of central nervous system involvement and to give preventive chemotherapy or radiotherapy.