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目的探讨心率变异性（HRV）在评估慢性肾衰（CRF）尿毒症期患者心脏损害和预后判断中的作用。方法采用清华-西安兰港监测系统对28例CRF尿毒症期患者进行24h动态心电图监测及HRV时域分析。结果尿毒症组患者HRV各项指标SDNN、SDSD、RMSSD、PNN50及三角指数均明显低于正常对照组（P＜0．01），提示其HRV降低。结论HRV可作为一种无创性评价尿毒症患者心脏自主神经功能的可靠方法，HRV下降可能是尿毒症患者发生心脏意外的危险信号。尿毒症时心脏自主神经功能不良可能是多种因素共同作用的结果。
Objective To investigate the role of heart rate variability (HRV) in assessing cardiac damage and prognosis in patients with uremia of chronic renal failure (CRF). Methods Twenty-eight patients with CRF uremia were monitored by the Qinghua-Xi’an Lan-Gang monitoring system for 24-hour Holter monitoring and HRV time domain analysis. Results The indexes of HRV, such as SDNN, SDSD, RMSSD, PNN50 and trigonometric index in patients with uremia were significantly lower than those in normal control group (P <0.01), which indicated that HRV decreased. Conclusion HRV can be used as a noninvasive method to evaluate cardiac autonomic nervous function in patients with uremia. The decrease of HRV may be a dangerous signal of cardiac accident in uremic patients. Uremia when the autonomic dysfunction of the heart may be the result of a combination of multiple factors.