目的探明长期氟暴露对儿童生长发育的影响。方法在氟中毒病区选取高氟区,并在相邻地区选择非高氟区作为对照组,分析比较两组间儿童生长发育水平的差异。结果高氟组儿童平均智商低于对照组(t=2.621,P<0.01);智商与儿童尿氟呈一定程度的负相关(r=-0.119,P<0.05)。高氟组儿童身高、体重均低于对照组(t=2.621,P<0.01;u=3.535,P<0.01)。结论长期氟暴露对儿童生长发育会产生一定的影响。针对氟暴露对儿童产生的危害,应积极采取综合防治措施,保护氟病区儿童的身体健康。 Objective To explore the effect of long-term fluoride exposure on children’s growth and development. Methods High fluoride area was selected in fluorosis area, and non-high fluoride area was selected as control group in adjacent area. The differences of growth and development of children between the two groups were analyzed and compared. Results The average IQ of children in high fluoride group was lower than that in control group (t = 2.621, P <0.01). There was a negative correlation between IQ and urinary fluoride (r = -0.119, P <0.05). Children in the high fluoride group had lower height and weight than those in the control group (t = 2.621, P <0.01; u = 3.535, P <0.01). Conclusion Long-term fluoride exposure has a certain impact on children’s growth and development. In view of the harm to children caused by fluoride exposure, comprehensive prevention and control measures should be actively taken to protect the health of children in fluorosis area.