本文报道用透射电镜观察脾虚证消化道粘膜主、壁、柱状细胞线粒体的变化,结果显示,胃脘痛脾虚型患者壁细胞线粒体数目比肝胃不和型和正常人明显减少;慢性结肠炎脾虚型患者结肠柱状细胞线柱体数也明显少于肝脾不调型和正常人;慢性胃炎脾虚者壁细胞、主细胞线粒体的体密度、数密度与胃热型和正常人比较明显降低,用健脾方药治疗后可以回升。提示脾虚证与消化道粘膜主、壁、柱状细胞的线粒体改变有密切关系。 In this paper, transmission electron microscopy was used to observe the mitochondrial changes in the main, wall and columnar cells of the digestive tract mucosa of the spleen deficiency syndrome. The results showed that the number of mitochondria in the parietal cells of the patients with epigastric pain and spleen deficiency was significantly lower than that in the liver-gastric discordant and normal persons; chronic colitis spleen deficiency The number of cylindrical columnar cells in patients with colonic colon was also significantly less than that in non-hepatosplenic patients and normal people; the body density and number density of parietal cells and main cell mitochondria in chronic gastritis and spleen deficiency were significantly lower than those in stomach-heat type and normal people. After the spleen prescription has been treated, it can rebound. It suggests that the spleen deficiency syndrome is closely related to the mitochondrial changes in the main, wall and columnar cells of the digestive tract mucosa.