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目的了解单独化疗对急性淋巴细胞白血病(ALL)患儿一氧化碳(CO)动态变化。方法应用Chalmers血红蛋白结合法及联二亚硫酸盐还原法检测了24例正常儿童,22例ALL患儿在化疗前、化疗中、缓解后以及长期缓解期血浆一氧化碳水平。结果ALL患儿化疗前血浆一氧化碳浓度为(1.98±0.26)mg/L,较正常儿童的(1.09±0.15)mg/L为高,差异有显著性意义(P>0.01),化疗中一氧化碳浓度(2.01±0.18)mg/L,缓解后(1.96±0.22)mg/L,差异无显著性意义(P>0.05),但长期缓解患儿血浆一氧化碳浓度为(1.10±0.16)mg/L,差异有显著性意义(P<0.01)。结论白血病化疗可使体内产生过量的一氧化碳,但随着时间的延长,这种影响会逐渐消失。
Objective To understand the dynamic changes of carbon monoxide (CO) in children with acute lymphoblastic leukemia (ALL) treated with chemotherapy alone. Methods Serum levels of carbon monoxide in 24 normal children and 22 children with ALL were measured before chemotherapy, during chemotherapy, after remission and after long-term remission by using Chalmers hemoglobin binding assay and dithionite-reducing assay. Results Before chemotherapy, plasma concentrations of carbon monoxide in patients with ALL were (1.98 ± 0.26) mg / L, which were significantly higher than those in normal children (1.09 ± 0.15) mg / L (P> 0.01) (1.12 ± 0.18) mg / L and 1.96 ± 0.22 mg / L respectively (P> 0.05), but the level of plasma CO was (1.10 ± 0.16) mg / L in children with long-term remission Significant significance (P <0.01). Conclusion Leukemia chemotherapy can produce excessive amounts of carbon monoxide in the body, but with the extension of time, this effect will gradually disappear.