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应激蛋白或热休克蛋白是细胞自身保护的一种内在本能。热休克蛋白是细胞或组织暴露在不足以致命的高热中合成的应激蛋白并对随后的高热应激反应产生耐受或抵抗,这类诱导的应激蛋白从细菌到人类的各种生物都存在,且诱导因素还包括低血糖、反应性氧(过氧化氢和超氧阴离子)和缺血等。动物和人类心肌均存在预处理的心肌保护现象,尽管70KDa热休克蛋白(HSP 70)族中的应激蛋白基因表达可在缺血鼠心脏中选择性诱导,但应激蛋白对预处理心肌是否有保护作用仍有争论,一项支持应激蛋白在预处理心肌中作用的研究表明:心肌缺血前使动物经过高热(诱导热休克蛋白效应)对心肌缺血和再灌注损伤有一定的保护作用,然而仅
Stress protein or heat shock protein is an inherent instinct of cell self-protection. Heat shock proteins are cells or tissues that are exposed to stress proteins synthesized in less than deadly hyperthermia and tolerant to or resistant to subsequent hyperthermic stress reactions. These inducers of stress proteins from bacteria to all kinds of human beings , And inducing factors also include hypoglycemia, reactive oxygen (hydrogen peroxide and superoxide anion) and ischemia and so on. Pretreatment myocardial protection exists in both animal and human myocardium. Although stress gene expression in the 70 kDa heat shock protein (HSP 70) family is selectively induced in the ischemic rat heart, There are still controversial protective effects, a study supporting the role of stress proteins in pretreatment of myocardium showed that: Myocardial ischemia before the animals hyperthermia (induction of heat shock protein effect) on myocardial ischemia and reperfusion injury with a certain degree of protection However, only