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目的应用心血管事件预测模型评估代谢综合征(MS)患者心血管事件(CVD)危险性。方法应用Framingham和缺血性心血管病(ICVD)心血管事件预测模型评估637例MS患者、259例2型糖尿病(T2DM)患者的心血管事件危险性,其中121例MS患者行心肌核素显像检查进行验证。结果MS组的绝对危险显著高于T2DM组(Framingham模型为9·55%vs1·47%,ICVD模型为8·62%vs4·28%,P<0·01)。MS组绝对危险≥5%的比例明显高于T2DM组(P<0·01)。随着年龄增大,MS组和T2DM组绝对危险≥10%的比例均呈增加趋势。Framingham模型评估男性绝对危险≥5%的比例明显高于女性;而ICVD模型评估女性绝对危险≥5%的比例明显高于男性。121例MS患者心肌核素检查显示Framingham模型评估的绝对危险越高心肌缺血程度越重。结论两模型对MS组心血管危险性的预测值均显著高于T2DM组,Framingham模型对MS患者的CHD有更好的预测效果。
Objective To assess the cardiovascular risk (CVD) risk of patients with metabolic syndrome (MS) using a cardiovascular event prediction model. Methods Six hundred and thirty-three patients with MS and 259 patients with type 2 diabetes mellitus (T2DM) were assessed for their risk of cardiovascular events using the Framingham and Ischemic Cardiovascular Disease (ICVD) cardiovascular event prediction model. 121 patients with MS underwent myocardial karyonin Like checking for verification. Results The absolute risk of MS group was significantly higher than that of T2DM group (Framingham model was 9.55% vs 1.47%, ICVD model was 8.22% vs 4.28%, P <0.01). The absolute risk of ≥5% in MS group was significantly higher than that in T2DM group (P <0.01). With age, the absolute risk of ≥10% in MS group and T2DM group showed an increasing trend. Framingham model to assess the absolute risk of men ≥ 5% was significantly higher than the proportion of women; and ICVD model to assess the absolute risk of women ≥ 5% was significantly higher than men. Myocardial nuclide examination in 121 MS patients showed that the absolute risk of Framingham model assessment was higher the more severe myocardial ischemia. Conclusions The predictive values of cardiovascular risk in MS group were significantly higher than those of T2DM group in the two models, and the Framingham model had better predictive value for CHD in MS patients.