论文部分内容阅读
目的探讨血清胱抑素C(Cys C)和视黄醇结合蛋白(RBP)在糖尿病肾病(DN)患者中的变化和临床应用价值。方法选取75例DN患者为疾病组,根据病情轻重以24小时尿白蛋白排泄率(24h-UAER)及尿蛋白由高到低分为A、B、C 3个亚组,另选择门诊健康体检者28例作为健康对照组,测定血清Cys C、RBP、尿素(UREA)、肌酐(Cr)、空腹血糖(FBG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbAlc)等指标。结果(1)病例组各亚组的Cys C、RBP、Cr、UREA、FBG和HbAlc水平均高于健康对照组,差异有统计学意义(P<0.05);(2)C组患者Cys C和RBP检测的阳性率分别为36%和32%,比UREA和Cr高;(3)病例组患者Cys C和RBP与24h-UAER呈正相关(P<0.01)。结论联合检测血清Cys C和RBP是反映肾小球损伤的重要指标,对疾病的发生、发展及预后有一定预警价值。
Objective To investigate the changes and clinical value of serum cystatin C (Cys C) and retinol binding protein (RBP) in patients with diabetic nephropathy (DN). Methods 75 patients with DN were selected as the disease group. According to the severity of the disease, 24-hour urinary albumin excretion (24h-UAER) and urine protein were divided into A, B and C subgroups from high to low, (N = 28) as healthy control group, serum Cys C, RBP, UREA, Cr, FBG, TG, TC and LDL LDL-C) and high-density lipoprotein cholesterol (HDL-C), glycosylated hemoglobin (HbAlc) and other indicators. Results (1) The levels of Cys C, RBP, Cr, UREA, FBG and HbAlc in each subgroup were significantly higher than those in healthy controls (P <0.05). (2) The Cys C and The positive rates of RBP were 36% and 32%, respectively, higher than those of UREA and Cr. (3) There was a positive correlation between Cys C and RBP and 24h-UAER (P <0.01). Conclusions The combined detection of serum Cys C and RBP is an important indicator of glomerular injury, which has some early warning value on the occurrence, development and prognosis of the disease.