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目的:研究低分子肝素对急性缺血性脑卒中患者高凝状态的影响。方法:观察50例缺血性脑卒中患者应用低分子肝素后凝血和抗凝血机制变化。结果:抗凝血酶活性在用药前为(0.870±0.064)IU药后10h为(1.115±1.104)IU(t=3.23,P<0.05,有显著性差异;组织型纤溶酶原激活酶活性在用药前、后分别为(1.51±0.21)、(2.30±1.03)IU,有极显著性差异t=8.43P<0.01。结论:低分子肝素可改善急性的缺血性脑卒中患者高凝状态,且没有出血倾向。
Objective: To investigate the effect of low molecular weight heparin on hypercoagulability in patients with acute ischemic stroke. Methods: The changes of coagulation and anticoagulant mechanism in 50 patients with ischemic stroke after low molecular weight heparin were observed. Results: The activity of antithrombin was (0.870 ± 0.064) before treatment and (1.115 ± 1.104) IU at 10h after treatment (t = 3.23, P <0.05). The activity of tissue plasminogen activator (1.51 ± 0.21) and (2.30 ± 1.03) IU respectively before and after treatment, with a significant difference of t = 8.43P <0.01.Conclusion: Low molecular weight heparin can improve hypercoagulability in acute ischemic stroke patients , And no bleeding tendency.