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过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor,PPARs)是配体活化的核转录因子,属Ⅱ型核受体超家族成员之一,有PPARα、PPARβ、PPARγ3种亚型。1990年Isseman等首次发现PPARγ,因可使过氧化物酶体增殖物激活而得名。三者在组织中的分布和表达不尽相
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear transcription factors and belong to the type Ⅱ nuclear receptor superfamily. There are three subtypes of PPARα, PPARβ and PPARγ. In 1990, Isseman et al found PPARγ for the first time because of the activation of peroxisome proliferator. The three are not evenly distributed and expressed in the organization