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目的：探讨帕罗西汀联合脑电生物反馈治疗强迫症患者的临床疗效。方法将100例强迫症患者随机分为两组，每组50例，均口服帕罗西汀治疗，在此基础上研究组联合脑电生物反馈治疗，观察6个月。治疗前后采用Yale‐Brow n强迫量表评定临床疗效。结果治疗后两组Yale‐Brown强迫量表评分均较治疗前显著下降（P＜0.05或0.01），研究组治疗各时点 Yale‐Brown强迫量表总分及强迫思维、强迫行为维度分均显著低于对照组（P＜0.05或0.01）。治疗6个月研究组总有效率为82.0％，对照组为48.0％，研究组显著高于对照组（χ2＝12.70， P＜0.01）。结论帕罗西汀联合脑电生物反馈治疗强迫症疗效显著，优于单用帕罗西汀治疗。“,”Objective To explore the efficacy of paroxetine combined with EEG biofeedback treatment for obsessive‐compulsive disorder (OCD) .Methods A total of 100 OCD patients were randomly assigned to two groups of 50 ones each ,both groups took orally paroxetine ,on this basis research group was plus EEG biofeedback treatment for 6 months .Efficacies were assessed with the Yale‐Brown Obsessive‐Com‐pulsive Scale (Y‐BOCS) before and after treatment .Results After treatment the Y‐BOCS scores of both groups lowered more significantly compared with pretreatment (P<0.05 or 0.01) ,in research group to‐tal ,obsessional thoughts and compulsive behavior scores at each time point were significantly lower com‐pared with those in control group (P<0.05 or 0.01) .The total effective rate was significantly higher in research than control group (82.0% vs 48.0% ,χ2 = 12.70 ,P< 0.01) .Conclusion Paroxetine combined with EEG biofeedback treatment for OCD has an evident effect compared with single paroxetine .