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二氟甲磺酸二氟甲酯HCF_2SO_3CF_2H(1)和三氟甲磺酸二氟甲酯CF_3SO_3CF_2H(2)相比,在亲核反应中显出较大的差异.由于α-氢的存在,在一定程度上影响了它和亲核试剂的反应,如KF和2作用时得到HCF_3.但与1反应却只进攻其硫原子,得到HCF_2SO_2F(3).而KI与1作用时既可进攻硫又可进攻其烷氧基碳.其它亲核试剂如RCO_2~-、ArS~-等却只进攻1的硫原子.碱性较强的苯酚钠和1作用时除分别进攻硫和碳外,还可攫取其氢原子而产生二氟卡宾.若反应温度较低时,则仅攫取其二氟甲基的氢;若于90℃反应,则还可同时攫取二氟甲氧基的氢.碱性更强的乙醇钠与1反应时则是以攫氢为主.
The difluoromethanesulfonic acid difluoromethyl HCF_2SO_3CF_2H (1) shows a large difference in the nucleophilic reaction compared with the difluoromethyl trifluoromethanesulfonate CF_3SO_3CF_2H (2). Due to the presence of α-hydrogen, The degree of influence on its reaction with the nucleophile, such as the role of KF and 2 get HCF_3, but with 1 reaction but attack its sulfur atom, get HCF_2SO_2F (3) .When KI and 1 can both attack the sulfur and attack Its alkoxy carbon.Other nucleophiles such as RCO_2 ~ -, ArS ~ - but only attack the sulfur atom 1. Alkaline phenol sodium and 1 in addition to the role of attack, respectively, in addition to sulfur and carbon, they can grab the Hydrogen atoms to produce difluorocarbene.If the reaction temperature is low, then only to take off the difluoromethyl hydrogen; if the reaction at 90 ° C, but also simultaneously capture difluoromethoxy hydrogen. Alkaline stronger When sodium ethylate is reacted with 1, it is mainly to grab hydrogen.