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观察采取先大剂量后小剂量基因重组人粒细胞集落刺激因子（Ｇ－ＣＳＦ），治疗消化道癌化疗后白细胞减少症的临床效果。对３０例患者进行前瞻性分组，初次化疗组和重复化疗组。化疗后４８ｈ以上，如果两次血常规检查白细胞数＜３．０×１０９／Ｌ，则采用惠尔血治疗。先大剂量皮下注射，待白细胞≥１０．０×１０９／Ｌ后，剂量减半维持７～１０天。治疗效果总有效率为９６．６％，６天内白细胞数１０．０×１０９／Ｌ的比率，初次化疗组明显高于重复化疗组。该实验提示采用先大剂量后小剂量惠尔血（Ｇ－ＣＳＦ）治疗消化道癌化疗后白细胞减少症有良好疗效。
Observe the clinical effect of high-dose, low-dose, recombinant human granulocyte colony-stimulating factor (G-CSF) in the treatment of leukopenia after chemotherapy in patients with digestive tract cancer. Thirty patients were prospectively divided into groups of primary chemotherapy and repeated chemotherapy. More than 48 hours after chemotherapy, if the two blood routine examination of white blood cell count <3.0 × 109 / L, the use of Whirlpool blood treatment. The first large dose of subcutaneous injection, until the white blood cells ≥ 10.0 × 109 / L, the dose halved to maintain 7 to 10 days. The total effective rate of treatment was 96.6%, and the ratio of white blood cells was 10.0×109/L in 6 days. The initial chemotherapy group was significantly higher than the repeated chemotherapy group. The experiment suggests that the use of large doses of low-dose whale blood (G-CSF) in the treatment of leukopenia after chemotherapy in gastrointestinal cancer has a good effect.