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姜黄素具有多种生物活性,结构修饰有利于提高其生物利用度及选择活性.实验以姜黄素与二溴乙烷反应,在其二酮结构的中间亚甲基位引入官能团,合成了3种化合物,其收率最高为53.00%,最低收率为5.50%.经室内毒力测定结果显示,3种化合物对朱砂叶螨均有一定的触杀效果,其中CM01在浓度为1.89 mg/mL时,其24 h、48 h对朱砂叶螨的校正死亡率分别为60.45%,80.45%,对应LC50为1.279 0 mg/mL、0.392 2 mg/mL;而姜黄素在浓度为5.0 mg/mL时,24 h、48 h对朱砂叶螨的死亡率分别为20.40%,50.8%,LC50依次为24.570 1 mg/mL和2.637 7 mg/mL.CM01对朱砂叶螨的杀螨活性较姜黄素有明显提高.
Curcumin has a variety of biological activity, structural modification is conducive to improve its bioavailability and activity selection.In this experiment, curcumin and dibromoethane reaction, the diketone structure in the middle of the methylene position of the introduction of functional groups, the synthesis of three The highest yield of compound was 53.00% and the lowest yield was 5.50% .According to the results of indoor toxicity assay, the three compounds all had certain contact effects on Tetranychus cinnabarinus, of which the concentration of CM01 was 1.89 mg / mL, The corrected mortalities of Tetranychus cinnabarinus at 24 h and 48 h were 60.45% and 80.45%, respectively, corresponding to LC50 of 1.279 0 mg / mL and 0.392 2 mg / mL, while curcumin at a concentration of 5.0 mg / mL h and 48 h respectively, the mortality rates of Tetranychus cinnabarinus were 20.40% and 50.8%, respectively, and the LC50 values were 24.570 1 mg / mL and 2.637 7 mg / mL, respectively.CM01 had significantly higher acaricidal activity against turf spider mites than curcumin.