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白血病抑制因子(LIF)能使巨核细胞增多进而使血小板数增多,是一种新的有潜力的治疗血小板减少症制剂。本文旨在证实经LIF刺激后血小板的功能正常。 将受试小鼠分为2个实验及其对照组:FD/LIF与FD组、rmLIF组和FCS/NS组。FD/LIF组的小鼠静注10~6个细胞其内含人LIF可拷贝基因,注入的细胞在小鼠骨髓、脾、淋巴结内扩增,约1～2月后小鼠体内的血小板开始增多;FD组小鼠注入10~6个
Leukemia inhibitory factor (LIF) can increase the number of megakaryocytes and thus increase the number of platelets, is a new potential for the treatment of thrombocytopenic agents. This article aims to demonstrate that platelets function properly after stimulation with LIF. The test mice were divided into two experiments and control group: FD / LIF and FD group, rmLIF group and FCS / NS group. The mice in the FD / LIF group were intravenously injected with 10 to 6 cells containing human LIF-copy gene, and the injected cells were expanded in the mouse bone marrow, spleen and lymph nodes. About 1 to 2 months later, the platelets in mice started Increased; FD group of mice injected 10 to 6